J Clin Immunol. 2007 Jan;27(1):19-35. Epub 2007 Jan 9.

Jagetia GC1, Aggarwal BB.A Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

Abstract

Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. Traditionally known for its an antiinflammatory effects, curcumin has been shown in the last two decades to be a potent immunomodulatory agent that can modulate the activation of T cells, B cells, macrophages, neutrophils, natural killer cells, and dendritic cells. Curcumin can also downregulate the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12, and chemokines, most likely through inactivation of the transcription factor NF-kappaB. Interestingly, however, curcumin at low doses can also enhance antibody responses. This suggests that curcumin’s reported beneficial effects in arthritis, allergy, asthma, atherosclerosis, heart disease, Alzheimer’s disease, diabetes, and cancer might be due in part to its ability to modulate the immune system. Together, these findings warrant further consideration of curcumin as a therapy for immune disorders.

Treating Post-Party Skin

Whether it’s one too many prosecco’s or being too tired to remove your makeup properly, the festive celebrations can wreak havoc upon your skin.

Alcohol dehydrates the body and skin, whilst also depriving it of vital vitamins and nutrients. This can result in causing the skin to look dull, sallow and tired come the morning after. What’s more, dehydrated skin can lead to premature ageing, whilst also encouraging skin conditions such as rosacea.

Here are our top tips for treating post-party skin…

Christmas Party: Last-Minute Beauty Prep

The festive season has started and among the last-minute Christmas shopping, decorating the tree and getting those final work emails sent, you still have time to prepare for the Christmas parties.

However busy you may be, finding the time to prep and prime yourself ready to take on any festive party can be as easy as putting your out of office on.

Here’s our last-minute step-by-step guide to shine this Christmas…

HOW TO WIN ROAD RACES- THE CHRIS THOMPSON BLOG

British endurance runner Chris Thompson is ready to run this weekend’s TCS New York City Marathon on Sunday 4 November 2018. As a member of Team proto-col and user of the brand’s range of natural nutrition, he spoke to us about his approach to road racing and passed on his tips on competing at the front.

Want gorgeous feet this summer? Get top toe tips from our expert podiatrist

The early summer weather makes us all want to bare our feet and feel fab in simple sandals. But for most the year, our feet are encased in socks, tights and winter boots and when they emerge into the sunshine they often look and feel grey and lifeless.

 

Follow these simple steps for sexy feet this summer.

5 ways to keep your skin healthy this summer

5 ways to keep your skin healthy this summer

With summer officially here, you’ve already swapped your winter jumpers and boots for summer dresses and sandals. Now’s the time to switch your skincare routine for the new season too. From UVA/UVB protection to washing away extra sweat and sebum, follow these skincare tips to keep your skin healthy and happy this summer.