Tagged – “collagen capsules”:

What is Collagen? part 2

proto-col collagen capsules

COLLAGEN SYNTHESIS AND ASSEMBLY

Collagen synthesis and assembly follows the normal pathway for a secreted protein.  The activation of fibroblasts in the connective tissues results in an increase in the production of collagen.  The mechanism of collagen formation is well known.

The genetic information encoded in the DNA is “read” (transcription process in the nucleus), the mature mRNA is then transported to the cytoplasm and “translated” (translation process) to produce the single polypeptide chains (α-chains) at the rough endoplasmatic reticulum (ER).  Each α-chain has a terminal peptide sequence, also known as trimerization domain, which drives the assembly of the longer precursors, which are termed procollagens.

Ribosome-bound mRNA is translated into growing preprocollagen molecules that are assembled inside the fibroblasts, into the lumen of the ER.

What is Collagen?

Collagen in the skin

THE COLLAGEN MOLECULE

Collagen is the main structural protein of the different connective tissues present in animals.  It is mostly found in fibrous tissues, such as tendons and ligaments, and is also abundant in corneas, cartilage, bones, blood vessels, the gut, and intervertebral discs.

Collagen is the major insoluble fibrous protein found in the extracellular matrix of the skin, together with elastin and hyaluronic acid.  The collagen family consists of 28 different proteins which account for 25% – 35% of the total protein mass in mammals and play a pivotal role in the structure of several tissues, such as skin and bones, providing rigidity and integrity.

The collagen story

collagen skincare ingredients grid

James Greenwell, Founder and Managing Director of proto-col and former captain of the GB Modern Pentathlon team turned a career threatening injury in 2003 into a brilliant business opportunity.

Whilst in training for the last international event of his career, James suffered a ruptured Achilles tendon in his right leg which looked set to end any hopes of competing again with his final competition just 14 weeks away. Turning to his background in nutrition and sports training and with input from his friend and former team-mate Professor Greg Whyte OBE, a former international modern pentathlete and Olympian and now one of the UK’s foremost physiologists, James began a course of powdered collagen – the only form it was available in at that stage.